prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of OSTC in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
OSTC
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: OSTC (oligosaccharyltransferase complex non-catalytic subunit)
Type: protein-coding
Summary: Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, protein binding, protein-macromolecule adaptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: Q9NRP0
Entrez ID: 58505
|
Does Knockout of NAA15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NAA15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: N-terminal protein amino acid acetylation, angiogenesis, cell differentiation, negative regulation of apoptotic process, positive regulation of DNA-templated transcription, protein stabilization; MF: RNA binding, acetyltransferase activator activity, acetyltransferase activity, protein binding, ribosome binding; CC: NatA complex, cytoplasm, cytosol, membrane, nuclear body, nucleus, transcription regulator complex
Pathways:
UniProt: Q9BXJ9
Entrez ID: 80155
|
Does Knockout of PCDHB4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
PCDHB4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PCDHB4 (protocadherin beta 4)
Type: protein-coding
Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, chemical synaptic transmission, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development, synapse assembly; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane, synapse
Pathways:
UniProt: Q9Y5E5
Entrez ID: 56131
|
Does Knockout of HCCS in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
HCCS
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HCCS (holocytochrome c synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: animal organ morphogenesis, cytochrome c-heme linkage, respiratory electron transport chain; MF: heme binding, holocytochrome-c synthase activity, lyase activity, metal ion binding, protein binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Respiratory electron transport
UniProt: P53701
Entrez ID: 3052
|
Does Knockout of TIMELESS in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
TIMELESS
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TIMELESS (timeless circadian regulator)
Type: protein-coding
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication checkpoint signaling, branching morphogenesis of an epithelial tube, cell cycle phase transition, cell division, cellular response to bleomycin, cellular response to cisplatin, cellular response to hydroxyurea, circadian rhythm, detection of abiotic stimulus, lung development, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, regulation of cell population proliferation, regulation of circadian rhythm, replication fork arrest, replication fork processing, rhythmic process; MF: DNA binding, enzyme activator activity, identical protein binding, protein binding; CC: chromatin, chromosome, nucleoplasm, nucleus, replication fork protection complex, site of double-strand break
Pathways: ATR signaling pathway, Circadian rhythm pathway, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q9UNS1
Entrez ID: 8914
|
Does Knockout of HMGCL in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
HMGCL
|
cell proliferation
|
Melanoma Cell Line
|
Gene: HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: L-leucine catabolic process, ketone body biosynthetic process, lipid metabolic process, mitochondrion organization; MF: catalytic activity, hydroxymethylglutaryl-CoA lyase activity, lyase activity, magnesium ion binding, manganese ion binding, metal ion binding, oxo-acid-lyase activity, structural molecule activity; CC: cytosol, mitochondrial matrix, mitochondrion, peroxisomal matrix, peroxisome, protein-containing complex
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Amino Acid metabolism, Beta-Ketothiolase Deficiency, Butanoate metabolism - Homo sapiens (human), Butyrate Metabolism, Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Ketone Body Metabolism, Ketone body metabolism, Maple Syrup Urine Disease, Metabolism, Metabolism of lipids, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Peroxisomal protein import, Peroxisome - Homo sapiens (human), Propionic Acidemia, Protein localization, Succinyl CoA: 3-ketoacid CoA transferase deficiency, Synthesis and Degradation of Ketone Bodies, Synthesis and degradation of ketone bodies - Homo sapiens (human), Synthesis of Ketone Bodies, Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), ketogenesis, leucine degradation
UniProt: P35914
Entrez ID: 3155
|
Does Knockout of UBR5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
UBR5
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, estrogen receptor signaling pathway, heterochromatin boundary formation, negative regulation of smoothened signaling pathway, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of protein import into nucleus, progesterone receptor signaling pathway, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein polyubiquitination, protein ubiquitination, response to oxidative stress, retinoic acid receptor signaling pathway, vitamin D receptor signaling pathway; MF: RNA binding, metal ion binding, protein binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Mesodermal commitment pathway, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: O95071
Entrez ID: 51366
|
Does Knockout of TERF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
TERF1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TERF1 (telomeric repeat binding factor 1)
Type: protein-coding
Summary: This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products. [provided by RefSeq, Aug 2022].
Gene Ontology: BP: cell division, meiotic telomere clustering, negative regulation of DNA replication, negative regulation of establishment of RNA localization to telomere, negative regulation of establishment of protein localization to telomere, negative regulation of establishment of protein-containing complex localization to telomere, negative regulation of telomere maintenance via semi-conservative replication, negative regulation of telomere maintenance via telomerase, negative regulation of telomere maintenance via telomere lengthening, negative regulation of telomeric D-loop disassembly, positive regulation of shelterin complex assembly, positive regulation of telomere maintenance, response to xenobiotic stimulus, t-circle formation, telomere capping, telomere maintenance, telomere maintenance via telomerase, telomeric D-loop disassembly; MF: DNA binding, DNA binding, bending, G-rich strand telomeric DNA binding, ankyrin repeat binding, double-stranded telomeric DNA binding, identical protein binding, microtubule binding, protein binding, protein homodimerization activity, telomerase activity, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, fibrillar center, nuclear body, nuclear telomere cap complex, nucleolus, nucleoplasm, nucleus, shelterin complex, spindle
Pathways: Regulation of Telomerase, telomeres telomerase cellular aging and immortality
UniProt: P54274
Entrez ID: 7013
|
Does Knockout of KRTAP5-7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
KRTAP5-7
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: KRTAP5-7 (keratin associated protein 5-7)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q6L8G8
Entrez ID: 440050
|
Does Knockout of KRT39 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
KRT39
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: KRT39 (keratin 39)
Type: protein-coding
Summary: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Homo sapiens (human), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Homo sapiens (human)
UniProt: Q6A163
Entrez ID: 390792
|
Does Knockout of RPS13 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RPS13
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, ribosomal small subunit biogenesis, translation; MF: RNA binding, mRNA 5'-UTR binding, mRNA binding, protein binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62277
Entrez ID: 6207
|
Does Knockout of TSPYL5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
TSPYL5
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: TSPYL5 (TSPY like 5)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Involved in several processes, including cellular response to gamma radiation; positive regulation of protein kinase B signaling; and positive regulation of protein ubiquitination. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to gamma radiation, nucleosome assembly, positive regulation of cell population proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein ubiquitination; MF: chromatin binding, histone binding, protein binding; CC: chromatin, nucleus
Pathways:
UniProt: Q86VY4
Entrez ID: 85453
|
Does Knockout of MED4 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
MED4
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9NPJ6
Entrez ID: 29079
|
Does Knockout of COL4A4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
COL4A4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: COL4A4 (collagen type IV alpha 4 chain)
Type: protein-coding
Summary: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: glomerular basement membrane development; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, molecular adaptor activity; CC: basement membrane, collagen trimer, collagen type IV trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Anchoring fibril formation, Assembly of collagen fibrils and other multimeric structures, Attachment of bacteria to epithelial cells, Axon guidance, Bacterial Infection Pathways, Beta1 integrin cell surface interactions, Beta3 integrin cell surface interactions, Biofilm formation, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Crosslinking of collagen fibrils, Degradation of the extracellular matrix, Developmental Biology, Disease, ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Extracellular matrix organization, Fibronectin matrix formation, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Infection with Enterobacteria, Infectious disease, Integrin cell surface interactions, Integrins in angiogenesis, Laminin interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nephrotic syndrome, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), Protein digestion and absorption - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Syndecan-1-mediated signaling events, intrinsic prothrombin activation pathway, regulators of bone mineralization
UniProt: P53420
Entrez ID: 1286
|
Does Knockout of TET2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
TET2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TET2 (tet methylcytosine dioxygenase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: chromatin organization, epigenetic regulation of gene expression, leukocyte differentiation, myeloid cell differentiation, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein O-linked glycosylation, regulation of gene expression; MF: 2-oxoglutarate-dependent dioxygenase activity, DNA 5-methylcytosine dioxygenase activity, DNA binding, dioxygenase activity, ferrous iron binding, metal ion binding, oxidoreductase activity, protein binding, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways: MECP2 and Associated Rett Syndrome
UniProt: Q6N021
Entrez ID: 54790
|
Does Knockout of SLC39A12 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
SLC39A12
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: SLC39A12 (solute carrier family 39 member 12)
Type: protein-coding
Summary: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008].
Gene Ontology: BP: bicarbonate transport, intracellular monoatomic cation homeostasis, metal ion transport, monoatomic ion transport, neural tube formation, neuron projection extension, regulation of microtubule polymerization, regulation of neuron projection development, signal transduction, transmembrane transport, zinc ion import across plasma membrane, zinc ion transport; MF: metal ion transmembrane transporter activity, monoatomic cation:bicarbonate symporter activity, zinc ion transmembrane transporter activity; CC: extracellular vesicle, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: NRF2 pathway, Nuclear Receptors Meta-Pathway, Zinc homeostasis
UniProt: Q504Y0
Entrez ID: 221074
|
Does Knockout of WDR17 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
WDR17
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: WDR17 (WD repeat domain 17)
Type: protein-coding
Summary: This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009].
Gene Ontology:
Pathways:
UniProt: Q8IZU2
Entrez ID: 116966
|
Does Knockout of NEK8 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
NEK8
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NEK8 (NIMA related kinase 8)
Type: protein-coding
Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, animal organ morphogenesis, determination of left/right symmetry, heart development, regulation of hippo signaling; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, centrosome, ciliary base, ciliary inversin compartment, cilium, cytoplasm, cytoskeleton
Pathways: Ciliary landscape, Ciliopathies, Joubert Syndrome
UniProt: Q86SG6
Entrez ID: 284086
|
Does Knockout of JAGN1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
JAGN1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: JAGN1 (jagunal vesicle mediated transporter 1)
Type: protein-coding
Summary: The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response to fungus, endoplasmic reticulum organization, exocytosis, granulocyte colony-stimulating factor signaling pathway, immune system process, insulin metabolic process, insulin secretion, negative regulation of insulin secretion involved in cellular response to glucose stimulus, neutrophil differentiation, neutrophil mediated immunity, neutrophil migration, protein transport, response to endoplasmic reticulum stress, response to glucose, vesicle-mediated transport; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8N5M9
Entrez ID: 84522
|
Does Knockout of RSPH10B in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
RSPH10B
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: RSPH10B (radial spoke head 10 homolog B)
Type: protein-coding
Summary: Predicted to enable kinase activity. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: 9+2 motile cilium, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: P0C881
Entrez ID: 222967
|
Does Knockout of ANAPC13 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ANAPC13
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ANAPC13 (anaphase promoting complex subunit 13)
Type: protein-coding
Summary: This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cell cycle, Cell cycle - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Immune System, Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9BS18
Entrez ID: 25847
|
Does Knockout of RGS14 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
RGS14
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RGS14 (regulator of G protein signaling 14)
Type: protein-coding
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell division, chromosome segregation, learning, long-term memory, long-term synaptic potentiation, mitotic cell cycle, modulation of chemical synaptic transmission, negative regulation of ERK1 and ERK2 cascade, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of MAP kinase activity, negative regulation of signal transduction, negative regulation of synaptic plasticity, nucleocytoplasmic transport, platelet-derived growth factor receptor signaling pathway, positive regulation of neurogenesis, regulation of G protein-coupled receptor signaling pathway, response to oxidative stress, signal transduction, spindle organization, visual learning, zygote asymmetric cell division; MF: G-protein alpha-subunit binding, GDP-dissociation inhibitor activity, GTPase activating protein binding, GTPase activator activity, GTPase activity, GTPase regulator activity, microtubule binding, protein binding, protein kinase binding, signaling receptor complex adaptor activity; CC: PML body, cell projection, centrosome, cytoplasm, cytoskeleton, dendrite, dendritic spine, glutamatergic synapse, membrane, microtubule, nuclear body, nucleus, plasma membrane, postsynaptic density, spindle, spindle pole, synapse
Pathways: Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, GPCR downstream signalling, Myometrial relaxation and contraction pathways, Rap1 signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: O43566
Entrez ID: 10636
|
Does Knockout of RELT in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
RELT
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: RELT (RELT TNF receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amelogenesis, apoptotic process; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human)
UniProt: Q969Z4
Entrez ID: 84957
|
Does Knockout of SRRD in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SRRD
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SRRD (SRR1 domain containing)
Type: protein-coding
Summary: Predicted to be involved in microtubule-based process; regulation of circadian rhythm; and regulation of heme biosynthetic process. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: heme biosynthetic process, regulation of circadian rhythm, regulation of heme biosynthetic process, rhythmic process; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9UH36
Entrez ID: 402055
|
Does Knockout of PDCD7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PDCD7
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PDCD7 (programmed cell death 7)
Type: protein-coding
Summary: This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: RNA splicing, apoptotic process, response to glucocorticoid; CC: U12-type spliceosomal complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q8N8D1
Entrez ID: 10081
|
Does Knockout of PYURF in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
PYURF
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: PYURF (PIGY upstream open reading frame)
Type: protein-coding
Summary: The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. [provided by RefSeq, Aug 2012].
Gene Ontology: CC: endoplasmic reticulum membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q96I23
Entrez ID: 100996939
|
Does Knockout of GGPS1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
GGPS1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GGPS1 (geranylgeranyl diphosphate synthase 1)
Type: protein-coding
Summary: This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, geranylgeranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, isoprenoid metabolic process, lipid metabolic process; MF: (2E,6E)-farnesyl diphosphate synthase activity, dimethylallyltranstransferase activity, geranylgeranyl diphosphate synthase activity, identical protein binding, metal ion binding, prenyl diphosphate synthase activity, prenyltransferase activity, protein binding, transferase activity; CC: Z disc, cytoplasm, cytosol, nucleoplasm, perinuclear region of cytoplasm
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Terpenoid backbone biosynthesis - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, geranylgeranyldiphosphate biosynthesis, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: O95749
Entrez ID: 9453
|
Does Knockout of CLRN1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
CLRN1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: CLRN1 (clarin 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament organization, auditory receptor cell development, auditory receptor cell stereocilium organization, cell motility, equilibrioception, neuromuscular process controlling balance, photoreceptor cell maintenance, positive regulation of lamellipodium assembly, sensory perception of light stimulus, sensory perception of sound, visual perception; CC: actin-based cell projection, basal part of cell, lamellipodium, membrane, microtubule cytoskeleton, microvillus, plasma membrane, stereocilium, trans-Golgi network transport vesicle
Pathways:
UniProt: P58418
Entrez ID: 7401
|
Does Knockout of APOA4 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
APOA4
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: APOA4 (apolipoprotein A4)
Type: protein-coding
Summary: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acylglycerol homeostasis, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron assembly, chylomicron remodeling, high-density lipoprotein particle remodeling, hydrogen peroxide catabolic process, innate immune response in mucosa, leukocyte cell-cell adhesion, lipid catabolic process, lipid homeostasis, lipid transport, lipoprotein metabolic process, negative regulation of plasma lipoprotein oxidation, peripheral nervous system axon regeneration, phosphatidylcholine metabolic process, phospholipid efflux, positive regulation of fatty acid biosynthetic process, positive regulation of triglyceride catabolic process, protein-lipid complex assembly, regulation of cholesterol transport, regulation of intestinal cholesterol absorption, removal of superoxide radicals, response to lipid hydroperoxide, response to stilbenoid, response to stress, response to triglyceride, reverse cholesterol transport, very-low-density lipoprotein particle remodeling; MF: antioxidant activity, cholesterol transfer activity, copper ion binding, identical protein binding, lipid binding, lipid transporter activity, phosphatidylcholine binding, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipid binding, protein binding, protein homodimerization activity; CC: blood microparticle, cell surface, chylomicron, cytosol, early endosome, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, extracellular vesicle, high-density lipoprotein particle, low-density lipoprotein particle, synapse, very-low-density lipoprotein particle
Pathways: Amyloid fiber formation, Assembly of active LPL and LIPC lipase complexes, Cholesterol metabolism - Homo sapiens (human), Chylomicron assembly, Chylomicron remodeling, Fat digestion and absorption - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Metabolism, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Retinoid metabolism and transport, Sensory Perception, Statin inhibition of cholesterol production, Transport of small molecules, Visual phototransduction, Vitamin digestion and absorption - Homo sapiens (human)
UniProt: P06727
Entrez ID: 337
|
Does Knockout of GTF2H3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
GTF2H3
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: GTF2H3 (general transcription factor IIH subunit 3)
Type: protein-coding
Summary: This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: DNA damage response, DNA repair, nucleotide-excision repair, regulation of DNA-templated transcription, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, protein binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription preinitiation complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: Q13889
Entrez ID: 2967
|
Does Knockout of TREML4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
TREML4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TREML4 (triggering receptor expressed on myeloid cells like 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Predicted to colocalize with endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: immune system process, innate immune response, positive regulation of toll-like receptor 7 signaling pathway; CC: cell surface, extracellular region, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q6UXN2
Entrez ID: 285852
|
Does Knockout of FAM25G in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
FAM25G
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FAM25G (family with sequence similarity 25 member G)
Type: protein-coding
Summary: family with sequence similarity 25 member G
Gene Ontology:
Pathways:
UniProt: B3EWG5, B3EWG3, B3EWG6
Entrez ID: 100133093
|
Does Knockout of RPL28 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
RPL28
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RPL28 (ribosomal protein L28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, extracellular exosome, membrane, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46779
Entrez ID: 6158
|
Does Knockout of HBM in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
HBM
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: HBM (hemoglobin subunit mu)
Type: protein-coding
Summary: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: erythrocyte development, oxygen transport; MF: heme binding, metal ion binding, oxygen binding, oxygen carrier activity, protein binding; CC: haptoglobin-hemoglobin complex, hemoglobin complex
Pathways:
UniProt: Q6B0K9
Entrez ID: 3042
|
Does Knockout of RTCB in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
RTCB
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA processing, in utero embryonic development, placenta development, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: GTP binding, RNA binding, RNA ligase (GTP) activity, ligase activity, ligase activity, forming phosphoric ester bonds, metal ion binding, nucleotide binding, protein binding, vinculin binding; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, nuclear envelope, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways: Metabolism of RNA, Unfolded protein response, tRNA processing, tRNA processing in the nucleus
UniProt: Q9Y3I0
Entrez ID: 51493
|
Does Knockout of KRTAP5-1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
KRTAP5-1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: KRTAP5-1 (keratin associated protein 5-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization, Vitamin D Receptor Pathway
UniProt: Q6L8H4
Entrez ID: 387264
|
Does Knockout of HNRNPL in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
HNRNPL
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: HNRNPL (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, mRNA processing, negative regulation of DNA-templated transcription, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA intronic binding, protein binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, extracellular exosome, membrane, nucleoplasm, nucleus, pronucleus, ribonucleoprotein complex, ribonucleoprotein granule, synapse
Pathways: mRNA Processing
UniProt: P14866
Entrez ID: 3191
|
Does Knockout of PCDHGC4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
PCDHGC4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: PCDHGC4 (protocadherin gamma subfamily C, 4)
Type: protein-coding
Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process, nervous system development, synapse organization; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9Y5F7
Entrez ID: 56098
|
Does Knockout of NDUFA8 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
NDUFA8
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: NADH dehydrogenase (ubiquinone) activity, protein binding, protein-containing complex binding; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: P51970
Entrez ID: 4702
|
Does Knockout of SNIP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SNIP1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, regulation of gene expression, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA binding, protein binding, transcription regulator inhibitor activity; CC: U2 snRNP, U2-type precatalytic spliceosome, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Regulation of nuclear SMAD2/3 signaling, TGF-beta Signaling Pathway, TGF_beta_Receptor, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8TAD8
Entrez ID: 79753
|
Does Knockout of MYBBP1A in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
MYBBP1A
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: MYBBP1A (MYB binding protein 1a)
Type: protein-coding
Summary: This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: cellular response to glucose starvation, chromatin remodeling, circadian regulation of gene expression, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of DNA-templated transcription, osteoblast differentiation, positive regulation of anoikis, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, regulation of DNA-templated transcription, regulation of G1 to G0 transition, respiratory electron transport chain, rhythmic process, ribosome biogenesis; MF: DNA binding, E-box binding, RNA binding, sequence-specific DNA binding, transcription corepressor activity; CC: B-WICH complex, NLS-dependent protein nuclear import complex, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Energy Metabolism, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression
UniProt: Q9BQG0
Entrez ID: 10514
|
Does Knockout of RPL36 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPL36
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL36 (ribosomal protein L36)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, nucleolus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3U8
Entrez ID: 25873
|
Does Knockout of COL11A1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
COL11A1
|
cell proliferation
|
Cancer Cell Line
|
Gene: COL11A1 (collagen type XI alpha 1 chain)
Type: protein-coding
Summary: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: cartilage condensation, cartilage development, chondrocyte development, collagen fibril organization, detection of mechanical stimulus involved in sensory perception of sound, embryonic skeletal system morphogenesis, endodermal cell differentiation, heart morphogenesis, inner ear morphogenesis, proteoglycan metabolic process, sensory perception of sound, skeletal system morphogenesis, tendon development, ventricular cardiac muscle tissue morphogenesis, visual perception; MF: extracellular matrix binding, extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, metal ion binding, protein-macromolecule adaptor activity; CC: collagen trimer, collagen type II trimer, collagen type XI trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region, fibrillar collagen trimer
Pathways: Assembly of collagen fibrils and other multimeric structures, Beta1 integrin cell surface interactions, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, Extracellular matrix organization, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Integrins in angiogenesis, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Homo sapiens (human), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Syndecan-1-mediated signaling events
UniProt: P12107
Entrez ID: 1301
|
Does Knockout of PKM in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PKM
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PKM (pyruvate kinase M1/2)
Type: protein-coding
Summary: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].
Gene Ontology: BP: canonical glycolysis, cellular response to insulin stimulus, chromatin remodeling, glycolytic process, positive regulation of cytoplasmic translation, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, programmed cell death, regulation of translation; MF: ATP binding, MHC class II protein complex binding, RNA binding, cadherin binding, catalytic activity, histone H3T11 kinase activity, kinase activity, mRNA binding, magnesium ion binding, metal ion binding, nucleotide binding, potassium ion binding, protein binding, protein homodimerization activity, protein tyrosine kinase activity, pyruvate kinase activity, transcription coactivator activity, transferase activity; CC: cilium, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular vesicle, ficolin-1-rich granule lumen, mitochondrion, nucleus, rough endoplasmic reticulum, secretory granule lumen, vesicle
Pathways: Aerobic respiration and respiratory electron transport, Amino Acid metabolism, Central carbon metabolism in cancer - Homo sapiens (human), Computational Model of Aerobic Glycolysis, EGFR1, Glucagon signaling pathway - Homo sapiens (human), Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Glycolysis in senescence, HIF-1-alpha transcription factor network, Human papillomavirus infection - Homo sapiens (human), Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pathways in clear cell renal cell carcinoma, Photodynamic therapy-induced HIF-1 survival signaling, Purine metabolism - Homo sapiens (human), Pyruvate metabolism, Pyruvate metabolism - Homo sapiens (human), Regulation of pyruvate metabolism, TCR, Type II diabetes mellitus - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Warburg Effect, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P14618
Entrez ID: 5315
|
Does Knockout of MBD3L3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
MBD3L3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MBD3L3 (methyl-CpG binding domain protein 3 like 3)
Type: protein-coding
Summary: Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, negative regulation of transcription by RNA polymerase II; MF: methyl-CpG binding, protein binding; CC: nucleus
Pathways:
UniProt: A6NE82
Entrez ID: 653657
|
Does Knockout of AMBN in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
AMBN
|
cell proliferation
|
Cancer Cell Line
|
Gene: AMBN (ameloblastin)
Type: protein-coding
Summary: This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: biomineral tissue development, cell adhesion, odontogenesis of dentin-containing tooth, regulation of cell population proliferation, signal transduction; MF: growth factor activity, protein binding, structural constituent of tooth enamel; CC: endoplasmic reticulum lumen, extracellular region
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q9NP70
Entrez ID: 258
|
Does Knockout of SRSF10 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
SRSF10
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SRSF10 (serine and arginine rich splicing factor 10)
Type: protein-coding
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, cytosolic transport, mRNA processing, mRNA splice site recognition, mRNA splicing, via spliceosome, negative regulation of mRNA splicing, via spliceosome, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: RNA binding, RS domain binding, mRNA binding, nucleic acid binding, protein binding, unfolded protein binding; CC: axon terminus, cytoplasm, cytosol, dendrite, neuronal cell body, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O75494
Entrez ID: 10772
|
Does Knockout of PPP2CA in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PPP2CA
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, intracellular signal transduction, meiotic cell cycle, mesoderm development, mitotic cell cycle, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, peptidyl-threonine dephosphorylation, positive regulation of NLRP3 inflammasome complex assembly, protein dephosphorylation, regulation of G1/S transition of mitotic cell cycle, regulation of cell differentiation, regulation of growth, regulation of microtubule polymerization, regulation of transcription by RNA polymerase II, response to lead ion, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vascular endothelial cell response to oscillatory fluid shear stress; MF: GABA receptor binding, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein heterodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, tau protein binding; CC: FAR/SIN/STRIPAK complex, INTAC complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, membrane raft, microtubule cytoskeleton, mitochondrion, nucleus, plasma membrane, protein phosphatase type 2A complex, protein serine/threonine phosphatase complex, spindle pole, synapse
Pathways: 16p11.2 proximal deletion syndrome, AMPK signaling pathway - Homo sapiens (human), ATR signaling pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, C-MYC pathway, Cancer immunotherapy by CTLA4 blockade, Chagas disease - Homo sapiens (human), Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), ErbB1 downstream signaling, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glycogen Synthesis and Degradation, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL3, IL8- and CXCR2-mediated signaling events, Long-term depression - Homo sapiens (human), Mesodermal commitment pathway, Oocyte meiosis - Homo sapiens (human), PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PLK1 signaling events, Regulation of retinoblastoma protein, Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human), TGF-beta receptor signaling, TGF-beta signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, Tight junction - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt, Wnt signaling pathway and pluripotency, akt signaling pathway, mRNA surveillance pathway - Homo sapiens (human), p53 pathway, regulation of eif-4e and p70s6 kinase
UniProt: P67775
Entrez ID: 5515
|
Does Knockout of RPL17 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
RPL17
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL17 (ribosomal protein L17)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P18621
Entrez ID: 6139
|
Does Knockout of LIMK2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
LIMK2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: LIMK2 (LIM domain kinase 2)
Type: protein-coding
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, astral microtubule organization, cornea development in camera-type eye, establishment of vesicle localization, head development, negative regulation of cilium assembly, positive regulation of protein localization to nucleus, protein phosphorylation, spermatogenesis; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, cis-Golgi network, cytoplasm, cytoskeleton, mitotic spindle, nucleus, perinuclear region of cytoplasm, spindle
Pathways: Androgen receptor signaling pathway, Axon guidance, Axon guidance - Homo sapiens (human), CDC42 signaling events, Developmental Biology, EGF-EGFR signaling pathway, EPH-Ephrin signaling, EPHB-mediated forward signaling, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Nervous system development, RHO GTPase Effectors, RHO GTPases Activate ROCKs, Regulation of actin cytoskeleton - Homo sapiens (human), RhoA signaling pathway, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TGF-beta Signaling Pathway
UniProt: P53671
Entrez ID: 3985
|
Does Knockout of FZR1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
FZR1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: FZR1 (fizzy and cell division cycle 20 related 1)
Type: protein-coding
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, DNA synthesis involved in mitotic DNA replication, anaphase-promoting complex-dependent catabolic process, cell division, lens fiber cell differentiation, mitotic G2 DNA damage checkpoint signaling, negative regulation of cellular senescence, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of ubiquitin protein ligase activity, protein K11-linked ubiquitination, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of meiotic cell cycle, regulation of meiotic nuclear division, regulation of mitotic cell cycle, thymidine biosynthetic process; MF: anaphase-promoting complex binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, cytoplasm, cytosol, nuclear membrane, nucleoplasm, nucleus
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Aurora A signaling, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Mitotic G2-G2/M phases, PLK1 signaling events, Phosphorylation of Emi1, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, SCF-beta-TrCP mediated degradation of Emi1, Senescence-Associated Secretory Phenotype (SASP), Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UM11
Entrez ID: 51343
|
Does Knockout of HMGA1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
HMGA1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: HMGA1 (high mobility group AT-hook 1)
Type: protein-coding
Summary: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: base-excision repair, intracellular signal transduction, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, nucleosome disassembly, oncogene-induced cell senescence, positive regulation of DNA-templated transcription, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression; MF: 5'-deoxyribose-5-phosphate lyase activity, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, enzyme binding, minor groove of adenine-thymine-rich DNA binding, molecular adaptor activity, molecular function activator activity, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, peroxisome proliferator activated receptor binding, protein binding, structural constituent of chromatin, transcription coactivator activity, transcription coregulator activity, transcription coregulator binding; CC: RNA polymerase II transcription regulator complex, chromatin, chromosome, cytosol, focal adhesion, nuclear membrane, nucleoplasm, nucleus, senescence-associated heterochromatin focus, transcription regulator complex
Pathways: Adipogenesis, IL4-mediated signaling events, Male infertility, NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, Pre-implantation embryo, Senescence and Autophagy in Cancer, Validated targets of C-MYC transcriptional activation, il 4 signaling pathway
UniProt: P17096
Entrez ID: 3159
|
Does Knockout of ASCC3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
ASCC3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ASCC3 (activating signal cointegrator 1 complex subunit 3)
Type: protein-coding
Summary: This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: CAT tailing, DNA alkylation repair, DNA damage response, DNA repair, DNA replication, protein monoubiquitination, protein ufmylation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, RNA binding, helicase activity, hydrolase activity, isomerase activity, nucleic acid binding, nucleotide binding, protein binding; CC: DNA repair complex, RQC-trigger complex, cytoplasm, cytosol, cytosolic ribosome, membrane, nuclear speck, nucleoplasm, nucleus
Pathways: ALKBH3 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, Mesodermal commitment pathway, Metabolism of proteins, Reversal of alkylation damage by DNA dioxygenases, Ribosome-associated quality control, Translation, VEGFA-VEGFR2 Signaling Pathway, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: Q8N3C0
Entrez ID: 10973
|
Does Knockout of SEPHS2 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
SEPHS2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SEPHS2 (selenophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017].
Gene Ontology: BP: selenium compound metabolic process, selenocysteine biosynthetic process, selenocysteine metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, selenide, water dikinase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of amino acids and derivatives, Selenium Micronutrient Network, Selenoamino Acid Metabolism, Selenoamino acid metabolism, Selenocompound metabolism - Homo sapiens (human), Selenocysteine synthesis, selenocysteine biosynthesis
UniProt: Q99611
Entrez ID: 22928
|
Does Knockout of ZNF713 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
ZNF713
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ZNF713 (zinc finger protein 713)
Type: protein-coding
Summary: The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals, a CGG-repeat expansion from 5-22 repeats to 68-450 repeats has been identified in the first intron of this gene. This mutation is thought to effect the expression of this gene and it has been proposed that it may be associated with Autistic Spectrum Disorder. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8N859
Entrez ID: 349075
|
Does Knockout of SS18L2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
SS18L2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SS18L2 (SS18 like 2)
Type: protein-coding
Summary: Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002].
Gene Ontology:
Pathways:
UniProt: Q9UHA2
Entrez ID: 51188
|
Does Knockout of TIMMDC1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
TIMMDC1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TIMMDC1 (translocase of inner mitochondrial membrane domain containing 1)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Implicated in nuclear type mitochondrial complex I deficiency 31. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q9NPL8
Entrez ID: 51300
|
Does Knockout of INCENP in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
INCENP
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: INCENP (inner centromere protein)
Type: protein-coding
Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell division, chromosome segregation, meiotic spindle midzone assembly, metaphase chromosome alignment, mitotic cell cycle, mitotic cytokinesis, mitotic spindle assembly, mitotic spindle midzone assembly, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid separation; MF: molecular function activator activity, protein binding; CC: central element, chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, lateral element, meiotic spindle midzone, microtubule, microtubule cytoskeleton, midbody, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin, protein-containing complex, spindle, synaptonemal complex
Pathways: Aurora B signaling, Aurora C signaling, PLK1 signaling events, Regulation of nuclear beta catenin signaling and target gene transcription
UniProt: Q9NQS7
Entrez ID: 3619
|
Does Knockout of ST7L in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ST7L
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ST7L (suppression of tumorigenicity 7 like)
Type: protein-coding
Summary: This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: negative regulation of cell growth
Pathways:
UniProt: Q8TDW4
Entrez ID: 54879
|
Does Knockout of UTP20 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
UTP20
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: UTP20 (UTP20 small subunit processome component)
Type: protein-coding
Summary: UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of cell population proliferation, rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: 90S preribosome, cytoplasm, nucleolus, nucleoplasm, nucleus, plasma membrane, preribosome, small subunit precursor, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O75691
Entrez ID: 27340
|
Does Knockout of TNFSF11 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
TNFSF11
|
response to virus
|
Hepatoma Cell Line
|
Gene: TNFSF11 (TNF superfamily member 11)
Type: protein-coding
Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: JNK cascade, animal organ morphogenesis, bone development, bone resorption, calcium ion homeostasis, calcium-mediated signaling, cell communication, cell differentiation, cell surface receptor signaling pathway, cellular response to leukemia inhibitory factor, cytokine-mediated signaling pathway, immune response, mammary gland alveolus development, mammary gland epithelial cell proliferation, monocyte chemotaxis, negative regulation of transcription by RNA polymerase II, ossification, osteoclast development, osteoclast differentiation, osteoclast proliferation, paracrine signaling, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of T cell activation, positive regulation of bone resorption, positive regulation of canonical NF-kappaB signal transduction, positive regulation of corticotropin-releasing hormone secretion, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of fever generation by positive regulation of prostaglandin secretion, positive regulation of gene expression, positive regulation of homotypic cell-cell adhesion, positive regulation of intracellular signal transduction, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of osteoclast development, positive regulation of osteoclast differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, regulation of osteoclast differentiation, signaling, tooth eruption, tumor necrosis factor-mediated signaling pathway; MF: cytokine activity, identical protein binding, protein binding, receptor ligand activity, signaling receptor binding, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Autosomal recessive Osteopetrosis pathways, Breast cancer - Homo sapiens (human), Breast cancer pathway, Cytokine-cytokine receptor interaction - Homo sapiens (human), Differentiation Pathway, IL-18 signaling pathway, IL6-mediated signaling events, Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), NF-kappa B signaling pathway - Homo sapiens (human), Osteoblast Signaling, Osteoclast Signaling, Osteoclast differentiation - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Prolactin signaling pathway - Homo sapiens (human), RANKL-RANK signaling pathway, Regucalcin in proximal tubule epithelial kidney cells, Rheumatoid arthritis - Homo sapiens (human), Type I collagen synthesis in the context of Osteogenesis imperfecta, Vitamin D Receptor Pathway, bone remodeling
UniProt: O14788
Entrez ID: 8600
|
Does Activation of USP45 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
USP45
|
protein/peptide accumulation
|
T cell
|
Gene: USP45 (ubiquitin specific peptidase 45)
Type: protein-coding
Summary: The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: DNA repair, cell migration, global genome nucleotide-excision repair, neural retina development, photoreceptor cell maintenance, protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, photoreceptor inner segment
Pathways: DNA Repair, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Nucleotide Excision Repair
UniProt: Q70EL2
Entrez ID: 85015
|
Does Knockout of IL11 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
IL11
|
cell proliferation
|
Cancer Cell Line
|
Gene: IL11 (interleukin 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: B cell differentiation, cell population proliferation, fat cell differentiation, interleukin-11-mediated signaling pathway, megakaryocyte differentiation, negative regulation of endothelial cell apoptotic process, negative regulation of hormone secretion, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of transcription by RNA polymerase II, regulation of complement-dependent cytotoxicity; MF: cytokine activity, growth factor activity, interleukin-11 receptor binding, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Differentiation Pathway, Glucocorticoid Receptor Pathway, Hematopoietic cell lineage - Homo sapiens (human), IL-6-type cytokine receptor ligand interactions, IL11, Immune System, Interleukin-11 Signaling Pathway, Interleukin-6 family signaling, JAK-STAT signaling pathway - Homo sapiens (human), Nuclear Receptors Meta-Pathway, Rheumatoid arthritis - Homo sapiens (human), Signaling by Interleukins, ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
UniProt: P20809
Entrez ID: 3589
|
Does Knockout of MFN2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
MFN2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MFN2 (mitofusin 2)
Type: protein-coding
Summary: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: aerobic respiration, apoptotic process, autophagy, blastocyst formation, camera-type eye morphogenesis, mitochondrial fusion, mitochondrial membrane organization, mitochondrion localization, mitochondrion organization, negative regulation of Ras protein signal transduction, negative regulation of smooth muscle cell proliferation, positive regulation of cold-induced thermogenesis, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell proliferation, protein localization to phagophore assembly site, protein targeting to mitochondrion, response to unfolded protein, type 2 mitophagy; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, ubiquitin protein ligase binding; CC: cytosol, membrane, microtubule cytoskeleton, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Factors involved in megakaryocyte development and platelet production, Hemostasis, Intracellular trafficking proteins involved in CMT neuropathy, Macroautophagy, Miro GTPase Cycle, Mitophagy, Mitophagy - animal - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RHOT2 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O95140
Entrez ID: 9927
|
Does Knockout of RAB1B in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
RAB1B
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: RAB1B (RAB1B, member RAS oncogene family)
Type: protein-coding
Summary: Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009].
Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagy, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of endothelial intestinal barrier, intracellular protein transport, positive regulation of glycoprotein metabolic process, protein transport, regulation of autophagosome assembly, virion assembly; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, membrane, perinuclear region of cytoplasm, phagophore assembly site membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cell Cycle, Cell Cycle, Mitotic, ER to Golgi Anterograde Transport, Golgi Cisternae Pericentriolar Stack Reorganization, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Legionellosis - Homo sapiens (human), M Phase, Membrane Trafficking, Metabolism of proteins, Mitotic Prophase, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9H0U4
Entrez ID: 81876
|
Does Knockout of TOPBP1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
TOPBP1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TOPBP1 (DNA topoisomerase II binding protein 1)
Type: protein-coding
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA metabolic process, DNA repair, DNA replication checkpoint signaling, DNA replication initiation, broken chromosome clustering, chromatin organization, chromosome organization, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via classical nonhomologous end joining, double-strand break repair via homologous recombination, homologous recombination, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, protein localization to site of double-strand break, response to ionizing radiation; MF: DNA binding, chromatin-protein adaptor activity, identical protein binding, phosphorylation-dependent protein binding, protein binding, protein serine/threonine kinase activator activity; CC: BRCA1-B complex, PML body, actin cytoskeleton, centrosome, chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, male germ cell nucleus, nuclear body, nucleoplasm, nucleus, plasma membrane, site of DNA damage, site of double-strand break, spindle pole
Pathways: ATR Signaling, ATR signaling pathway, BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, E2F transcription factor network, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q92547
Entrez ID: 11073
|
Does Knockout of XRCC6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
XRCC6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: XRCC6 (X-ray repair cross complementing 6)
Type: protein-coding
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, activation of innate immune response, cellular hyperosmotic salinity response, cellular response to X-ray, cellular response to gamma radiation, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of macromolecule biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of protein kinase activity, positive regulation of transcription by RNA polymerase II, recombinational repair, regulation of smooth muscle cell proliferation, response to ionizing radiation, telomere maintenance; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA end binding, DNA helicase activity, RNA binding, catalytic activity, cyclin binding, damaged DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, helicase activity, hydrolase activity, lyase activity, nucleotide binding, protein binding, protein-containing complex binding, scaffold protein binding, telomeric DNA binding, transcription cis-regulatory region binding; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, chromosome, telomeric region, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, membrane, nonhomologous end joining complex, nuclear telomere cap complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, secretory granule lumen, transcription regulator complex
Pathways: 2-LTR circle formation, AndrogenReceptor, BARD1 signaling events, Coregulation of Androgen receptor activity, Cytosolic sensors of pathogen-associated DNA , DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA-PK pathway in nonhomologous end joining, Disease, Early Phase of HIV Life Cycle, HIV Infection, HIV Life Cycle, IRF3-mediated induction of type I IFN, Immune System, Infectious disease, Innate Immune System, Integration of provirus, Neutrophil degranulation, Non-homologous end joining, Non-homologous end-joining - Homo sapiens (human), Nonhomologous End-Joining (NHEJ), Regulation of Telomerase, STING mediated induction of host immune responses, Signaling events mediated by HDAC Class III, Viral Infection Pathways, telomeres telomerase cellular aging and immortality
UniProt: P12956
Entrez ID: 2547
|
Does Knockout of YBEY in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
YBEY
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: YBEY (ybeY metalloendoribonuclease)
Type: protein-coding
Summary: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, nuclease activity, protein binding; CC: mitochondrion, nucleus
Pathways:
UniProt: P58557
Entrez ID: 54059
|
Does Knockout of COX4I1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
COX4I1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: COX4I1 (cytochrome c oxidase subunit 4I1)
Type: protein-coding
Summary: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: cellular respiration, generation of precursor metabolites and energy, mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation, proton transmembrane transport, response to nutrient; MF: cytochrome-c oxidase activity, protein binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial CIV Assembly, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Homo sapiens (human), Transcriptional Regulation by TP53
UniProt: P13073
Entrez ID: 1327
|
Does Knockout of KCTD19 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
KCTD19
|
response to virus
|
Lung Cancer Cell Line
|
Gene: KCTD19 (potassium channel tetramerization domain containing 19)
Type: protein-coding
Summary: Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, male meiotic nuclear division, meiotic cell cycle, protein homooligomerization, spermatogenesis; MF: identical protein binding, protein binding; CC: nucleus
Pathways:
UniProt: Q17RG1
Entrez ID: 146212
|
Does Activation of SYNGR3 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
SYNGR3
|
protein/peptide accumulation
|
T cell
|
Gene: SYNGR3 (synaptogyrin 3)
Type: protein-coding
Summary: This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: positive regulation of transporter activity, regulated exocytosis, regulation of neurotransmitter uptake, regulation of synaptic vesicle priming, substantia nigra development; MF: SH2 domain binding, protein binding; CC: cytoplasmic vesicle, membrane, neuromuscular junction, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: O43761
Entrez ID: 9143
|
Does Knockout of PSMD8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
PSMD8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PSMD8 (proteasome 26S subunit, non-ATPase 8)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, protein-containing complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P48556
Entrez ID: 5714
|
Does Knockout of PSTPIP1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
PSTPIP1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1)
Type: protein-coding
Summary: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: cell adhesion, endocytosis, immune system process, inflammatory response, innate immune response, signal transduction; MF: identical protein binding, protein binding; CC: cell projection, cleavage furrow, cytoplasm, cytoskeleton, cytosol, lamellipodium, membrane, perinuclear region of cytoplasm, plasma membrane, uropod
Pathways: Cell recruitment (pro-inflammatory response), Disease, Immune System, Infectious disease, Inflammasomes, Innate Immune System, Leishmania infection, NOD-like receptor signaling pathway - Homo sapiens (human), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Parasitic Infection Pathways, Purinergic signaling in leishmaniasis infection, T-cell receptor (TCR) signaling pathway, TCR, The NLRP3 inflammasome
UniProt: O43586
Entrez ID: 9051
|
Does Knockout of BRI3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
BRI3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: BRI3 (brain protein I3)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding; CC: azurophil granule membrane, cytoplasm, lysosomal membrane, lysosome, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: O95415
Entrez ID: 25798
|
Does Knockout of GNPNAT1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
GNPNAT1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in late endosome. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: UDP-N-acetylglucosamine biosynthetic process, cellular response to leukemia inhibitory factor; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, glucosamine 6-phosphate N-acetyltransferase activity, identical protein binding, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endoplasmic reticulum-Golgi intermediate compartment, endosome, endosome membrane, late endosome, membrane
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, Amino Sugar Metabolism, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, G(M2)-Gangliosidosis: Variant B, Tay-sachs disease, Glutamate Metabolism, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Metabolism of proteins, Post-translational protein modification, Salla Disease/Infantile Sialic Acid Storage Disease, Sialuria or French Type Sialuria, Succinic semialdehyde dehydrogenase deficiency, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, Tay-Sachs Disease, UDP-<i>N</i>-acetyl-D-galactosamine biosynthesis II, UDP-<i>N</i>-acetyl-D-glucosamine biosynthesis II
UniProt: Q96EK6
Entrez ID: 64841
|
Does Knockout of PRSS54 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
PRSS54
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: PRSS54 (serine protease 54)
Type: protein-coding
Summary: This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: proteolysis; MF: serine-type endopeptidase activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q6PEW0
Entrez ID: 221191
|
Does Knockout of ZBTB39 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
ZBTB39
|
response to virus
|
Huh-7 Cell
|
Gene: ZBTB39 (zinc finger and BTB domain containing 39)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: O15060
Entrez ID: 9880
|
Does Knockout of ELOC in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
ELOC
|
cell proliferation
|
Cancer Cell Line
|
Gene: ELOC (elongin C)
Type: protein-coding
Summary: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: protein ubiquitination, regulation of transcription by RNA polymerase II, target-directed miRNA degradation, transcription initiation at RNA polymerase II promoter, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, transcription corepressor binding; CC: Cul2-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, cytoplasm, cytosol, elongin complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Dual hijack model of Vif in HIV infection, HIF-1 signaling pathway - Homo sapiens (human), HIF-2-alpha transcription factor network, Hijack of ubiquitination by SARS-CoV-2, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Pathways in cancer - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway
UniProt: Q15369
Entrez ID: 6921
|
Does Knockout of SRP19 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SRP19
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, cotranslational protein targeting to membrane; MF: 7S RNA binding, RNA binding, protein binding, ribosome binding; CC: cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P09132
Entrez ID: 6728
|
Does Activation of SCAPER in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
SCAPER
|
protein/peptide accumulation
|
T cell
|
Gene: SCAPER (S-phase cyclin A associated protein in the ER)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: antral ovarian follicle growth, ovarian follicle development, retina development in camera-type eye, seminiferous tubule development, spermatogenesis; MF: metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nuclear speck, nucleoplasm, nucleus, ooplasm, sperm head
Pathways:
UniProt: Q9BY12
Entrez ID: 49855
|
Does Knockout of SUPV3L1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
SUPV3L1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA recombination, RNA catabolic process, mitochondrial RNA 3'-end processing, mitochondrial RNA catabolic process, mitochondrial RNA surveillance, mitochondrial mRNA catabolic process, mitochondrial mRNA surveillance, mitochondrial ncRNA surveillance, mitochondrion organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of mitochondrial RNA catabolic process; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: mitochondrial degradosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: Metabolism of RNA, Mitochondrial RNA degradation
UniProt: Q8IYB8
Entrez ID: 6832
|
Does Knockout of MIR3164 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
MIR3164
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR3164 (microRNA 3164)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100422846
|
Does Knockout of ATL2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
ATL2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATL2 (atlastin GTPase 2)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi organization, endoplasmic reticulum membrane fusion, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum tubular network membrane organization, protein homooligomerization; MF: GTP binding, GTPase activity, GTPase-dependent fusogenic activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network membrane, membrane
Pathways:
UniProt: Q8NHH9
Entrez ID: 64225
|
Does Knockout of UBA5 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
UBA5
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: UBA5 (ubiquitin like modifier activating enzyme 5)
Type: protein-coding
Summary: This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: erythrocyte differentiation, megakaryocyte differentiation, neuromuscular process, protein K69-linked ufmylation, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, regulation of type II interferon production, response to endoplasmic reticulum stress, reticulophagy; MF: ATP binding, UFM1 activating enzyme activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, ubiquitin-like modifier activating enzyme activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9GZZ9
Entrez ID: 79876
|
Does Knockout of FEM1A in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
FEM1A
|
cell proliferation
|
T-lymphoma cell line
|
Gene: FEM1A (fem-1 homolog A)
Type: protein-coding
Summary: Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: MAPK cascade, negative regulation of inflammatory response, positive regulation of inflammatory response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of ubiquitin-protein transferase activity, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: EP4 subtype prostaglandin E2 receptor binding, molecular adaptor activity, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm, cytosol, mitochondrion, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9BSK4
Entrez ID: 55527
|
Does Knockout of NOL12 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
NOL12
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single-stranded DNA binding; CC: cytoplasm, nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UGY1
Entrez ID: 79159
|
Does Knockout of SPTSSB in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
SPTSSB
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: SPTSSB (serine palmitoyltransferase small subunit B)
Type: protein-coding
Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: ceramide biosynthetic process, endoplasmic reticulum organization, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingosine biosynthetic process; MF: protein binding, serine C-palmitoyltransferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism
UniProt: Q8NFR3
Entrez ID: 165679
|
Does Knockout of PHF12 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PHF12
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PHF12 (PHD finger protein 12)
Type: protein-coding
Summary: Enables phosphatidylinositol binding activity and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3 complex and transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II; MF: metal ion binding, phosphatidylinositol binding, protein binding, transcription corepressor activity, transcription corepressor binding, zinc ion binding; CC: Sin3-type complex, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: Q96QT6
Entrez ID: 57649
|
Does Knockout of ACTR10 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
ACTR10
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ACTR10 (actin related protein 10)
Type: protein-coding
Summary: Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microtubule-based movement, retrograde axonal transport of mitochondrion; CC: axon cytoplasm, azurophil granule lumen, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular region, ficolin-1-rich granule lumen
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), TCR, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9NZ32
Entrez ID: 55860
|
Does Activation of MPST in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
MPST
|
response to virus
|
Hepatoma Cell Line
|
Gene: MPST (mercaptopyruvate sulfurtransferase)
Type: protein-coding
Summary: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cyanate catabolic process, hydrogen sulfide biosynthetic process, kidney development, liver development, response to toxic substance, spinal cord development, sulfur amino acid catabolic process, transsulfuration; MF: 3-mercaptopyruvate sulfurtransferase activity, identical protein binding, protein binding, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity; CC: cytoplasm, extracellular exosome, mitochondrial matrix, mitochondrion, neuron projection, synapse
Pathways: Amino Acid metabolism, Beta-mercaptolactate-cysteine disulfiduria, Cysteine Metabolism, Cysteine and methionine metabolism - Homo sapiens (human), Cystinosis, ocular nonnephropathic, Degradation of cysteine and homocysteine, L-cysteine degradation II, Metabolism, Metabolism of amino acids and derivatives, Sulfur amino acid metabolism, Sulfur metabolism - Homo sapiens (human), Sulfur relay system - Homo sapiens (human), Trans-sulfuration pathway
UniProt: P25325
Entrez ID: 4357
|
Does Knockout of PUS7L in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
PUS7L
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: PUS7L (pseudouridine synthase 7 like)
Type: protein-coding
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA modification, mRNA processing, mRNA pseudouridine synthesis, pseudouridine synthesis; MF: RNA binding, isomerase activity, protein binding, pseudouridine synthase activity
Pathways:
UniProt: Q9H0K6
Entrez ID: 83448
|
Does Knockout of F13A1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
F13A1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: F13A1 (coagulation factor XIII A chain)
Type: protein-coding
Summary: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, blood coagulation, fibrin clot formation, hemostasis, peptide cross-linking; MF: acyltransferase activity, metal ion binding, protein binding, protein-glutamine gamma-glutamyltransferase activity, transferase activity; CC: blood microparticle, cytoplasm, extracellular matrix, extracellular region, extracellular space, platelet alpha granule lumen, transferase complex
Pathways: Acenocoumarol Action Pathway, Alpha9 beta1 integrin signaling events, Alteplase Action Pathway, Aminocaproic Acid Action Pathway, Anistreplase Action Pathway, Aprotinin Action Pathway, Ardeparin Action Pathway, Argatroban Action Pathway, Beta1 integrin cell surface interactions, Bivalirudin Action Pathway, Coagulation , Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Homo sapiens (human), Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Dicoumarol Action Pathway, Dicumarol Action Pathway, Enoxaparin Action Pathway, Fondaparinux Action Pathway, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Heparin Action Pathway, Immune System, Interleukin-4 and Interleukin-13 signaling, Lepirudin Action Pathway, Phenindione Action Pathway, Phenprocoumon Action Pathway, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Reteplase Action Pathway, Signaling by Interleukins, Streptokinase Action Pathway, Tenecteplase Action Pathway, Tranexamic Acid Action Pathway, Urokinase Action Pathway, Warfarin Action Pathway, Ximelagatran Action Pathway
UniProt: P00488
Entrez ID: 2162
|
Does Knockout of C8orf34 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
C8orf34
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: C8orf34 (chromosome 8 open reading frame 34)
Type: protein-coding
Summary: This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017].
Gene Ontology:
Pathways:
UniProt: Q49A92
Entrez ID: 116328
|
Does Knockout of GRAMD1B in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
GRAMD1B
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GRAMD1B (GRAM domain containing 1B)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol and cholesterol homeostasis. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to cholesterol, cholesterol homeostasis, intracellular sterol transport, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding, phosphatidic acid binding, phosphatidylserine binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, organelle membrane contact site, plasma membrane
Pathways: Ectoderm Differentiation
UniProt: Q3KR37
Entrez ID: 57476
|
Does Knockout of ATP6V0B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
ATP6V0B
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATP6V0B (ATPase H+ transporting V0 subunit b)
Type: protein-coding
Summary: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: Golgi lumen acidification, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, vacuolar acidification; MF: protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: Golgi membrane, clathrin-coated vesicle membrane, cytoplasmic vesicle, endosome, endosome membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q99437
Entrez ID: 533
|
Does Knockout of SSB in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
SSB
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: SSB (small RNA binding exonuclease protection factor La)
Type: protein-coding
Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: IRES-dependent viral translational initiation, RNA processing, histone mRNA metabolic process, nuclear histone mRNA catabolic process, positive regulation of translation, protein localization to cytoplasmic stress granule, tRNA 3'-end processing, tRNA 5'-leader removal, tRNA export from nucleus, tRNA modification, tRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding, poly(U) RNA binding, protein binding, sequence-specific mRNA binding, tRNA binding; CC: chromosome, telomeric region, cytoplasm, cytoplasmic stress granule, cytosol, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Termination, Systemic lupus erythematosus - Homo sapiens (human)
UniProt: P05455
Entrez ID: 6741
|
Does Knockout of CEP55 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
CEP55
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: CEP55 (centrosomal protein 55)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centriolar satellite; and plasma membrane. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cranial skeletal system development, establishment of protein localization, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, nucleus organization, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: identical protein binding, protein binding; CC: Flemming body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, membrane, midbody
Pathways:
UniProt: Q53EZ4
Entrez ID: 55165
|
Does Knockout of ARAP2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
ARAP2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)
Type: protein-coding
Summary: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: regulation of actin cytoskeleton organization, signal transduction; MF: GTPase activator activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, zinc ion binding; CC: cytoplasm
Pathways: Arf6 signaling events, CDC42 GTPase cycle, Endocytosis - Homo sapiens (human), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, adp-ribosylation factor, rac1 cell motility signaling pathway, rho cell motility signaling pathway, t cell receptor signaling pathway
UniProt: Q8WZ64
Entrez ID: 116984
|
Does Knockout of MRPL55 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
MRPL55
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MRPL55 (mitochondrial ribosomal protein L55)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q7Z7F7
Entrez ID: 128308
|
Does Knockout of DNAI1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
DNAI1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DNAI1 (dynein axonemal intermediate chain 1)
Type: protein-coding
Summary: This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cell projection organization, cilium movement, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, heart development, insulin receptor signaling pathway, outer dynein arm assembly; MF: cytoskeletal motor activity, dynein heavy chain binding, dynein light chain binding, protein binding; CC: 9+2 motile cilium, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, dynein axonemal particle, dynein complex, extracellular region, glial cell projection, microtubule, microtubule cytoskeleton, outer dynein arm
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Ciliopathies, Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: Q9UI46
Entrez ID: 27019
|
End of preview. Expand
in Data Studio
README.md exists but content is empty.
- Downloads last month
- 32