Entrez ID
int64 47
103M
⌀ | Gene symbol
stringclasses 866
values | Gene name
stringclasses 866
values | Cancer Cell
stringclasses 2
values | Type of senescence
stringclasses 4
values | Senescence Effect
stringclasses 3
values | Reference
int64 1.56M
33.5M
⌀ |
|---|---|---|---|---|---|---|
22,848
|
AAK1
|
AP2 associated kinase 1
|
No
|
Unclear
|
Induces
| 26,583,757
|
5,243
|
ABCB1
|
ATP binding cassette subfamily B member 1
|
Yes
|
Stress-induced
|
Induces
| 10,825,123
|
368
|
ABCC6
|
ATP binding cassette subfamily C member 6
|
Yes
|
Unclear
|
Inhibits
| 28,536,638
|
51,225
|
ABI3
|
ABI family member 3
|
Yes
|
Oncogene-induced
|
Induces
| 21,223,585
|
25,890
|
ABI3BP
|
ABI family member 3 binding protein
|
Yes
|
Unclear
|
Induces
| 18,559,958
|
340,485
|
ACER2
|
alkaline ceramidase 2
|
Yes
|
Replicative
|
Inhibits
| 29,229,990
|
340,485
|
ACER2
|
alkaline ceramidase 2
|
Yes
|
Stress-induced
|
Inhibits
| 29,229,990
|
2,532
|
ACKR1
|
atypical chemokine receptor 1 (Duffy blood group)
|
No
|
Stress-induced
|
Induces
| 17,955,335
|
47
|
ACLY
|
ATP citrate lyase
|
No
|
Unclear
|
Inhibits
| 25,367,309
|
203,054
|
ADCK5
|
aarF domain containing kinase 5
|
No
|
Unclear
|
Induces
| 26,583,757
|
27,161
|
AGO2
|
argonaute RISC catalytic component 2
|
No
|
Oncogene-induced
|
Inhibits
| 25,175,024
|
10,551
|
AGR2
|
anterior gradient 2, protein disulphide isomerase family member
|
Yes
|
Oncogene-induced
|
Inhibits
| 22,467,239
|
183
|
AGT
|
angiotensinogen
|
No
|
Stress-induced
|
Induces
| 16,908,765
|
196
|
AHR
|
aryl hydrocarbon receptor
|
No
|
Stress-induced
|
Induces
| 15,111,621
|
8,852
|
AKAP4
|
A-kinase anchoring protein 4
|
Yes
|
Unclear
|
Inhibits
| 26,590,805
|
231
|
AKR1B1
|
aldo-keto reductase family 1 member B
|
Yes
|
Stress-induced
|
Inhibits
| 21,182,935
|
207
|
AKT1
|
AKT serine/threonine kinase 1
|
No
|
Oncogene-induced
|
Induces
| 17,045,205
|
84,335
|
AKT1S1
|
AKT1 substrate 1
|
Yes
|
Oncogene-induced
|
Inhibits
| 24,704,832
|
10,000
|
AKT3
|
AKT serine/threonine kinase 3
|
Yes
|
Stress-induced
|
Inhibits
| 26,972,278
|
64,400
|
AKTIP
|
AKT interacting protein
|
No
|
Replicative
|
Inhibits
| 27,512,140
|
217
|
ALDH2
|
aldehyde dehydrogenase 2 family member
|
No
|
Stress-induced
|
Inhibits
| 30,538,807
|
226
|
ALDOA
|
aldolase, fructose-bisphosphate A
|
Yes
|
Oncogene-induced
|
Inhibits
| 28,806,777
|
221,120
|
ALKBH3
|
alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
|
Yes
|
Unclear
|
Inhibits
| 21,285,982
|
247
|
ALOX15B
|
arachidonate 15-lipoxygenase type B
|
No
|
Unclear
|
Induces
| 17,164,141
|
64,682
|
ANAPC1
|
anaphase promoting complex subunit 1
|
No
|
Unclear
|
Inhibits
| 25,255,445
|
54,443
|
ANLN
|
anillin actin binding protein
|
Yes
|
Unclear
|
Inhibits
| 27,863,473
|
308
|
ANXA5
|
annexin A5
|
No
|
Replicative
|
Inhibits
| 22,728,018
|
308
|
ANXA5
|
annexin A5
|
No
|
Stress-induced
|
Inhibits
| 22,728,018
|
328
|
APEX1
|
apurinic/apyrimidinic endodeoxyribonuclease 1
|
No
|
Replicative
|
Inhibits
| 29,750,271
|
367
|
AR
|
androgen receptor
|
No
|
Unclear
|
Induces
| 24,244,503
|
375
|
ARF1
|
ADP ribosylation factor 1
|
No
|
Oncogene-induced
|
Induces
| 29,420,297
|
384
|
ARG2
|
arginase 2
|
No
|
Unclear
|
Induces
| 23,832,324
|
384
|
ARG2
|
arginase 2
|
No
|
Unclear
|
Induces
| 22,928,666
|
8,289
|
ARID1A
|
AT-rich interaction domain 1A
|
No
|
Oncogene-induced
|
Induces
| 28,942,143
|
57,492
|
ARID1B
|
AT-rich interaction domain 1B
|
No
|
Oncogene-induced
|
Induces
| 27,737,960
|
1,820
|
ARID3A
|
AT-rich interaction domain 3A
|
No
|
Oncogene-induced
|
Inhibits
| 11,812,999
|
51,742
|
ARID4B
|
AT-rich interaction domain 4B
|
Yes
|
Oncogene-induced
|
Induces
| 16,479,010
|
10,095
|
ARPC1B
|
actin related protein 2/3 complex subunit 1B
|
Yes
|
Unclear
|
Induces
| 21,628,992
|
408
|
ARRB1
|
arrestin beta 1
|
Yes
|
Unclear
|
Induces
| 31,204,931
|
427
|
ASAH1
|
N-acylsphingosine amidohydrolase 1
|
Yes
|
Unclear
|
Inhibits
| 28,785,021
|
25,842
|
ASF1A
|
anti-silencing function 1A histone chaperone
|
No
|
Replicative
|
Induces
| 15,621,527
|
25,842
|
ASF1A
|
anti-silencing function 1A histone chaperone
|
No
|
Oncogene-induced
|
Induces
| 15,621,527
|
444
|
ASPH
|
aspartate beta-hydroxylase
|
Yes
|
Unclear
|
Inhibits
| 26,683,595
|
55,252
|
ASXL2
|
ASXL transcriptional regulator 2
|
No
|
Unclear
|
Induces
| 26,416,890
|
467
|
ATF3
|
activating transcription factor 3
|
Yes
|
Stress-induced
|
Inhibits
| 25,046,976
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Replicative
|
Induces
| 28,803,844
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Stress-induced
|
Induces
| 28,803,844
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Oncogene-induced
|
Induces
| 28,803,844
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Replicative
|
Induces
| 30,260,700
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Stress-induced
|
Induces
| 30,260,700
|
22,926
|
ATF6
|
activating transcription factor 6
|
No
|
Oncogene-induced
|
Induces
| 30,260,700
|
55,729
|
ATF7IP
|
activating transcription factor 7 interacting protein
|
No
|
Stress-induced
|
Inhibits
| 23,935,871
|
83,734
|
ATG10
|
autophagy related 10
|
Yes
|
Unclear
|
Induces
| 23,451,179
|
9,140
|
ATG12
|
autophagy related 12
|
No
|
Unclear
|
Inhibits
| 21,858,089
|
55,054
|
ATG16L1
|
autophagy related 16 like 1
|
Yes
|
Unclear
|
Unclear
| 22,684,298
|
84,971
|
ATG4D
|
autophagy related 4D cysteine peptidase
|
No
|
Unclear
|
Inhibits
| 30,352,807
|
9,474
|
ATG5
|
autophagy related 5
|
No
|
Oncogene-induced
|
Inhibits
| 19,279,323
|
10,533
|
ATG7
|
autophagy related 7
|
No
|
Oncogene-induced
|
Inhibits
| 19,279,323
|
472
|
ATM
|
ATM serine/threonine kinase
|
No
|
Replicative
|
Inhibits
| 9,312,059
|
23,545
|
ATP6V0A2
|
ATPase H+ transporting V0 subunit a2
|
No
|
Unclear
|
Inhibits
| 26,611,489
|
527
|
ATP6V0C
|
ATPase H+ transporting V0 subunit c
|
No
|
Unclear
|
Inhibits
| 30,352,807
|
545
|
ATR
|
ATR serine/threonine kinase
|
Yes
|
Oncogene-induced
|
Induces
| 18,245,444
|
51,374
|
ATRAID
|
all-trans retinoic acid induced differentiation factor
|
Yes
|
Unclear
|
Induces
| 26,934,949
|
546
|
ATRX
|
ATRX chromatin remodeler
|
Yes
|
Oncogene-induced
|
Induces
| 28,855,512
|
546
|
ATRX
|
ATRX chromatin remodeler
|
Yes
|
Stress-induced
|
Induces
| 28,855,512
|
25,814
|
ATXN10
|
ataxin 10
|
No
|
Unclear
|
Induces
| 21,740,549
|
6,790
|
AURKA
|
aurora kinase A
|
Yes
|
Unclear
|
Inhibits
| 23,324,396
|
9,212
|
AURKB
|
aurora kinase B
|
No
|
Unclear
|
Inhibits
| 22,024,481
|
558
|
AXL
|
AXL receptor tyrosine kinase
|
No
|
Unclear
|
Induces
| 26,583,757
|
9,531
|
BAG3
|
BAG cochaperone 3
|
Yes
|
Unclear
|
Inhibits
| 25,412,315
|
8,314
|
BAP1
|
BRCA1 associated protein 1
|
No
|
Unclear
|
Induces
| 26,416,890
|
11,177
|
BAZ1A
|
bromodomain adjacent to zinc finger domain 1A
|
Yes
|
Unclear
|
Inhibits
| 31,085,244
|
64,919
|
BCL11B
|
BAF chromatin remodeling complex subunit BCL11B
|
Yes
|
Unclear
|
Inhibits
| 26,096,706
|
596
|
BCL2
|
BCL2 apoptosis regulator
|
No
|
Oncogene-induced
|
Induces
| 12,670,482
|
598
|
BCL2L1
|
BCL2 like 1
|
Yes
|
Oncogene-induced
|
Inhibits
| 28,948,203
|
599
|
BCL2L2
|
BCL2 like 2
|
Yes
|
Oncogene-induced
|
Induces
| 30,318,121
|
602
|
BCL3
|
BCL3 transcription coactivator
|
No
|
Unclear
|
Inhibits
| 25,255,445
|
604
|
BCL6
|
BCL6 transcription repressor
|
No
|
Replicative
|
Inhibits
| 11,914,273
|
9,774
|
BCLAF1
|
BCL2 associated transcription factor 1
|
Yes
|
Stress-induced
|
Induces
| 26,794,446
|
8,678
|
BECN1
|
beclin 1
|
Yes
|
Unclear
|
Inhibits
| 29,991,800
|
8,553
|
BHLHE40
|
basic helix-loop-helix family member e40
|
Yes
|
Replicative
|
Induces
| 18,025,081
|
8,553
|
BHLHE40
|
basic helix-loop-helix family member e40
|
Yes
|
Stress-induced
|
Induces
| 18,025,081
|
8,553
|
BHLHE40
|
basic helix-loop-helix family member e40
|
Yes
|
Replicative
|
Induces
| 22,844,531
|
8,553
|
BHLHE40
|
basic helix-loop-helix family member e40
|
Yes
|
Stress-induced
|
Induces
| 22,844,531
|
274
|
BIN1
|
bridging integrator 1
|
No
|
Oncogene-induced
|
Induces
| 18,267,069
|
332
|
BIRC5
|
baculoviral IAP repeat containing 5
|
Yes
|
Oncogene-induced
|
Inhibits
| 27,531,889
|
640
|
BLK
|
BLK proto-oncogene, Src family tyrosine kinase
|
No
|
Unclear
|
Induces
| 26,583,757
|
644
|
BLVRA
|
biliverdin reductase A
|
No
|
Stress-induced
|
Inhibits
| 21,099,244
|
648
|
BMI1
|
BMI1 proto-oncogene, polycomb ring finger
|
No
|
Replicative
|
Inhibits
| 12,482,990
|
652
|
BMP4
|
bone morphogenetic protein 4
|
Yes
|
Replicative
|
Induces
| 19,269,967
|
652
|
BMP4
|
bone morphogenetic protein 4
|
Yes
|
Stress-induced
|
Induces
| 19,269,967
|
659
|
BMPR2
|
bone morphogenetic protein receptor type 2
|
Yes
|
Replicative
|
Induces
| 27,696,331
|
9,790
|
BMS1
|
BMS1 ribosome biogenesis factor
|
Yes
|
Replicative
|
Inhibits
| 25,732,822
|
9,790
|
BMS1
|
BMS1 ribosome biogenesis factor
|
Yes
|
Oncogene-induced
|
Inhibits
| 25,732,822
|
665
|
BNIP3L
|
BCL2 interacting protein 3 like
|
No
|
Oncogene-induced
|
Induces
| 18,267,069
|
673
|
BRAF
|
B-Raf proto-oncogene, serine/threonine kinase
|
No
|
Oncogene-induced
|
Induces
| 16,079,850
|
672
|
BRCA1
|
BRCA1 DNA repair associated
|
Yes
|
Stress-induced
|
Inhibits
| 19,372,557
|
23,476
|
BRD4
|
bromodomain containing 4
|
Yes
|
Unclear
|
Inhibits
| 29,434,197
|
29,117
|
BRD7
|
bromodomain containing 7
|
No
|
Replicative
|
Induces
| 20,660,729
|
83,990
|
BRIP1
|
BRCA1 interacting helicase 1
|
No
|
Oncogene-induced
|
Inhibits
| 22,137,763
|
End of preview. Expand
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🧬 Human Ageing Genomic Resources (HAGR)
This dataset collection is derived from the Human Ageing Genomic Resources (HAGR), a curated set of databases focusing on the genetics of human aging, longevity, and cellular senescence. It includes several valuable resources formatted as .parquet files for easy use in data science and machine learning pipelines.
📦 Files Included
drugage.parquet: Database of drugs that affect lifespan in model organisms.genage_human.parquet: Genes associated with aging in humans.genage_models.parquet: Aging-related genes in model organisms.longevity.parquet: Genetic variants linked to human longevity.cellage3.parquet: Genes associated with cellular senescence.signatures1.parquet: Transcriptional signatures related to age-associated biological pathways.
🔧 Usage Instructions
import pandas as pd
# Example: Load DrugAge
df = pd.read_parquet("drugage.parquet")
print(df.head())
You can load all other .parquet files in the same way.
🔬 Use Cases
- Build predictive models of aging or lifespan using genetic or pharmacological features.
- Identify potential gene-drug-longevity interactions.
- Benchmark aging clocks against curated biological evidence.
- Perform feature importance analysis on senescence-related targets.
- Develop explainable AI models for aging biology.
📚 Citation
Please cite the original HAGR resource:
de Magalhães, J. P., et al. (2009). The Human Ageing Genomic Resources: new tools for ageing research. Nucleic Acids Research, 37(Database issue), D756–D759.
DOI: 10.1093/nar/gkn777
Official site: https://genomics.senescence.info
🙏 Acknowledgments
Data curated and maintained by the Human Ageing Genomic Resources project.
Formatting and conversion to .parquet for ML use by ### 🧑💻 Team: MultiModalMillenials. Iris Lee (@iris8090)
🗂️ License
Please review individual dataset licenses on https://genomics.senescence.info. Most data is freely available for academic and non-commercial use.
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